Which of the following is incorrect regarding gene annotation?(a) The gene annotation of the human genome employs a combination of theoretical prediction and experimental verification(b) Gene structures are first predicted by ab initio exon prediction programs(c) The predicted genes are compared with experimentally determined cDNA and EST sequences(d) The pairwise alignment programs are not involvedThis question was posed to me in final exam.My enquiry is from Genome Annotation in portion Genome Mapping, Assembly and Comparison of Bioinformatics

Which of the following is incorrect regarding gene annotation?(a) The

1.	Which of the following is incorrect regarding gene annotation?(a) The gene annotation of the human genome employs a combination of theoretical prediction and experimental verification(b) Gene structures are first predicted by ab initio exon prediction programs(c) The predicted genes are compared with experimentally determined cDNA and EST sequences(d) The pairwise alignment programs are not involvedThis question was posed to me in final exam.My enquiry is from Genome Annotation in portion Genome Mapping, Assembly and Comparison of Bioinformatics
Answer» The correct OPTION is (d) The pairwise alignment programs are not involved The explanation: The predictions are VERIFIED by BLAST searches against a sequence database. The PREDICTED genes are further COMPARED with experimentally DETERMINED cDNA and EST sequences using the pairwise alignment programs such as GeneWise, Spidey, SIM4, and EST2 Genome.

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