Which of the following is not correct about the β-sheet?(a) A β-sheet is a fully extended configuration built up from several spatially adjacent regions of a polypeptide chain(b) Each region involved in forming the β-sheet is a β-strand(c) The β-strand conformation is pleated with main chain backbone zigzagging and side chains positioned on same sides of the sheet(d) β-Strands are stabilized by hydrogen bonds between residues of adjacent strandsI had been asked this question in an online quiz.Question is taken from Protein Structure Basics in section Structural Bioinformatics of Bioinformatics

Which of the following is not correct about the β-sheet?(a) A β-shee

1.	Which of the following is not correct about the β-sheet?(a) A β-sheet is a fully extended configuration built up from several spatially adjacent regions of a polypeptide chain(b) Each region involved in forming the β-sheet is a β-strand(c) The β-strand conformation is pleated with main chain backbone zigzagging and side chains positioned on same sides of the sheet(d) β-Strands are stabilized by hydrogen bonds between residues of adjacent strandsI had been asked this question in an online quiz.Question is taken from Protein Structure Basics in section Structural Bioinformatics of Bioinformatics
Answer» The correct option is (c) The β-strand conformation is pleated with main CHAIN backbone zigzagging and side chains positioned on same sides of the sheet Easy explanation: The β-strand conformation is pleated with main chain backbone zigzagging and side chains positioned alternately on OPPOSITE sides of the sheet. β-strands NEAR the surface of the protein tend to show an alternating pattern of hydrophobic and hydrophilic regions, whereas strands BURIED at the core of a protein are NEARLY all hydrophobic. The β-strands can run in the same direction to form a parallel sheet or can run every other chain in reverse orientation to form an antiparallel sheet or a mixture of both.

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