1.

Which of the following is used in molecular encapsulation of drugs for enhancing bioavailability?(a) Highly water-soluble compound(b) Cyclodextrin(c) Inorganic clays like bentonite(d) Creating metastable polymorphsThis question was addressed to me during an interview.My doubt stems from Bioavailability topic in chapter Compartment Modelling, Non Linear Pharmacokinetics, Bioavailability and Bioequivalence of Drug Biotechnology

Answer»

The correct option is (b) Cyclodextrin

The explanation: Beta and GAMMA Cyclodextrin and other DERIVATIVES have the ABILITY to form molecular inclusion COMPLEXES with hydrophobic drugs having poor aqueous solubility. These Cyclodextrin molecules have a hydrophobic cavity which can accommodate the lipophilic drugs as a guest. The outside of which is hydrophilic.



Discussion

No Comment Found

Related InterviewSolutions