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What will be the particle size after micronization of drugs?(a) 1-10 micron(b) 10-20 micron(c) 20-30 micron(d) 1-5 micronI had been asked this question in an online interview.My doubt stems from Bioavailability topic in section Compartment Modelling, Non Linear Pharmacokinetics, Bioavailability and Bioequivalence of Drug Biotechnology

Answer»

Right answer is (a) 1-10 micron

The best explanation: MICRONIZATION is a process where the size of the solid drug particles is reduced to 1-10 microns by SPRAY DRYING or by using air attrition methods. Drugs such as GRISEOFULVIN and several steroidal and sulfa drugs are there whose bioavailability is increased by micronization.



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