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Which of the following will not be a parameter that should be examined for urinary excretion data?(a) (dXu/dt)max(b) (tu)max(c) Xu(d) CmaxI got this question during an online exam.My question is taken from Bioavailability in chapter Compartment Modelling, Non Linear Pharmacokinetics, Bioavailability and Bioequivalence of Drug Biotechnology

Answer»

The correct answer is (d) Cmax

Easy explanation: (dXu/dt)max is the maximum urinary excretion rate. It is analogous to Cmax from plasma level STUDIES since the rate of appearance of DRUG in the urine is proportional to its concentration in CIRCULATION. Its value increases as the rate of absorption increases. (TU)max is the time for maximum excretion rate, its value decreases as the absorption rate increases. Xu is the cumulative amount of drug excreted in the urine.



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