Which of the following least describes Long Loop β-hairpins?(a) They are Often referred to as a ‘random coil’ conformation(b) Generally they are referred to as the β-meander supersecondary structure(c) Loop looks similar to the Greek Letter Ω(d) Wide-range of conformations with very specific sequence preferencesThe question was posed to me in a job interview.I need to ask this question from Protein Motifs and Domain Prediction in section Sequence Alignment of Bioinformatics

Which of the following least describes Long Loop β-hairpins?(a) They

1.	Which of the following least describes Long Loop β-hairpins?(a) They are Often referred to as a ‘random coil’ conformation(b) Generally they are referred to as the β-meander supersecondary structure(c) Loop looks similar to the Greek Letter Ω(d) Wide-range of conformations with very specific sequence preferencesThe question was posed to me in a job interview.I need to ask this question from Protein Motifs and Domain Prediction in section Sequence Alignment of Bioinformatics
Answer» The correct option is (d) Wide-range of conformations with very specific sequence PREFERENCES The explanation: They are wide-range of conformations with no particular sequence preferences. As the NAME SUGGESTS ‘meander’ the conformation they possess is also QUITE unspecified. Addition to that Long loop β-hairpins are special case of Ω loops, that explains a LOT about their structural preferences.

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