Who suggested that the global alignment scores between unrelated protein sequences followed the extreme value distribution, similar to local alignment scores? And when?(a) Abagyan and Batalov, in 1981(b) Chvátal and Lipman, in 1984(c) Abagyan and Batalov, in 1997(d) Chvátal and Sankoff, in 1995This question was posed to me during an interview.I'd like to ask this question from Assessing the Significance of Sequence Alignments topic in portion Sequence Alignment of Bioinformatics

Who suggested that the global alignment scores between unrelated prote

1.	Who suggested that the global alignment scores between unrelated protein sequences followed the extreme value distribution, similar to local alignment scores? And when?(a) Abagyan and Batalov, in 1981(b) Chvátal and Lipman, in 1984(c) Abagyan and Batalov, in 1997(d) Chvátal and Sankoff, in 1995This question was posed to me during an interview.I'd like to ask this question from Assessing the Significance of Sequence Alignments topic in portion Sequence Alignment of Bioinformatics
Answer» The correct ANSWER is (c) Abagyan and Batalov, in 1997 For explanation I would say: Abagyan and Batalov, in 1997, suggested the above observation. HOWEVER, since the scoring system that they used favored LOCAL alignments, these alignments they produced may not be global but local. Unfortunately, there is no EQUIVALENT theory on which to base an analysis of global alignment scores as there is for local alignment scores.

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