Which one of the following is not an environmental agent to decrease drug metabolizing ability?(a) DDT(b) Cigarette smoke(c) Organophosphate insecticides(d) MethacholineI got this question in a job interview.This interesting question is from Drugs Biotransformation in division Biotransformation of Drugs of Drug Biotechnology

Which one of the following is not an environmental agent to decrease d

1.	Which one of the following is not an environmental agent to decrease drug metabolizing ability?(a) DDT(b) Cigarette smoke(c) Organophosphate insecticides(d) MethacholineI got this question in a job interview.This interesting question is from Drugs Biotransformation in division Biotransformation of Drugs of Drug Biotechnology
Answer» Correct choice is (d) Methacholine The explanation: Methacholine inhibits the metabolism of ACETYLCHOLINE by competing with it for cholinesterase. It is not an environmental FACTOR. Halogenated pesticides e.g. DDT, polycyclic aromatic hydrocarbon e.g. CIGARETTE smoke, ORGANOPHOSPHATE insecticides, heavy METALS inhibit drug metabolizing of enzymes.

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