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Which one of the following is reactive and a known carcinogenic?(a) Cytochrome P-450(b) Catechol(c) Glutathione(d) Arene oxideI had been asked this question in an international level competition.The origin of the question is Drugs Biotransformation topic in portion Biotransformation of Drugs of Drug Biotechnology

Answer»

The correct ANSWER is (d) ARENE oxide

The best I can explain: The OXIDATION of aromatic carbon atoms proceeds via formation of a reactive intermediate arene oxide. This arene oxide is a known carcinogenic or even CYTOTOXIC in some instances.



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