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Antigens that do not require the involvement of T-cells for the activation of B-cells are _____________________(a) thymus-dependent(b) thymus-independent(c) intracellular pathogens(d) facultative anaerobesI had been asked this question in an online interview.This interesting question is from Immune Response topic in section Immune Response of Cell Biology

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Correct OPTION is (b) thymus-independent

To elaborate: T-cells are usually involved in the process of activation of B-cells and subsequent production of a SINGLE type of ANTIBODY. Few antigens such as polysaccharides of BACTERIAL cell walls do not REQUIRE the involvement of T-cells and therefore termed thymus-independent antigens.



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