Any changes in fraction bioavailable, elimination half-life indicates nonlinearity of that particular drug.(a) True(b) FalseThe question was asked by my college professor while I was bunking the class.This interesting question is from Non Linearity of Drugs in division Compartment Modelling, Non Linear Pharmacokinetics, Bioavailability and Bioequivalence of Drug Biotechnology

Any changes in fraction bioavailable, elimination half-life indicates

1.	Any changes in fraction bioavailable, elimination half-life indicates nonlinearity of that particular drug.(a) True(b) FalseThe question was asked by my college professor while I was bunking the class.This interesting question is from Non Linearity of Drugs in division Compartment Modelling, Non Linear Pharmacokinetics, Bioavailability and Bioequivalence of Drug Biotechnology
Answer» Right option is (a) True Easiest explanation: Some of the pharmacokinetic FACTORS such as fraction bioavailable, ELIMINATION half-life or TOTAL systemic clearance at different DOSES of drug normally remains constant. If any changes occur in these constants, this indicates nonlinearity.

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