AP endonuclease can cleave the DNA at__________ while AP lyase will cleave the DNA at__________(a) 5’, 3’(b) 3’, 3’(c) 3’, 5’(d) 5’, 5’I had been asked this question in an interview.I'd like to ask this question from Repair of DNA Damage: MMR, BER in section DNA Mutation, DNA Repair, Transposable Elements of Cytogenetics

AP endonuclease can cleave the DNA at__________ while AP lyase will cl

1.	AP endonuclease can cleave the DNA at__________ while AP lyase will cleave the DNA at__________(a) 5’, 3’(b) 3’, 3’(c) 3’, 5’(d) 5’, 5’I had been asked this question in an interview.I'd like to ask this question from Repair of DNA Damage: MMR, BER in section DNA Mutation, DNA Repair, Transposable Elements of Cytogenetics
Answer» Right answer is (a) 5’, 3’ The best explanation: The AP endonuclease can CLEAVE at the 5’ END of the Apurinic or Apyrimidine site, while the bifunctional AP LYASE cleaves at the 3’ end.

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