1.

You are studying a mutational hot spot in the promoter region of a gene. Which type of mutation will you expect the most in this case?(a) Deamination(b) Depurination(c) Methylation(d) Frame shiftI had been asked this question in an online interview.The origin of the question is DNA Mutation topic in portion DNA Mutation, DNA Repair, Transposable Elements of Cytogenetics

Answer»

Right ANSWER is (a) Deamination

To elaborate: Mutational hot SPOTS are REGIONS which are rich in 5MC and these on deamination give a T base. Under normal condition deamination of C gives a U which is spontaneously excised out, but as T is a normal DNA base the MUTATION is fixed.



Discussion

No Comment Found

Related InterviewSolutions