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At which of the four marked points of the plasma drug concentration versus time graph, absorption rate = elimination rate?(a) a(b) b(c) c(d) dThis question was addressed to me in unit test.My enquiry is from One & Two Compartment Open Model in chapter Compartment Modelling, Non Linear Pharmacokinetics, Bioavailability and Bioequivalence of Drug Biotechnology

Answer»

The correct answer is (a) a

Easy explanation: At Cmax, where the plasma concentration rate is at the maximum that is ABSORPTION rate is at the maximum at that POINT for that short INTERVAL of TIME the ELIMINATION rate is equal to the absorption rate.



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