Baffles are not needed in Up and down agitation bioreactor.(a) True(b) FalseI had been asked this question during an interview.My doubt is from Bioreactor Configurations in division Reactor Engineering of Bioprocess Engineering

Baffles are not needed in Up and down agitation bioreactor.(a) True(b)

1.	Baffles are not needed in Up and down agitation bioreactor.(a) True(b) FalseI had been asked this question during an interview.My doubt is from Bioreactor Configurations in division Reactor Engineering of Bioprocess Engineering
Answer» The correct answer is (a) True The EXPLANATION is: Up and down agitators are useful to avoid shear stress to the cells. These are done by INSTEAD of a traditional PROPELLER agitator, which requires an expensive motor and magnetic coupling. Vertical up and down motion is achieved by a motor together with an inexpensive membrane perfectly assure sterility and produce an efficient mixing without formation of a vortex (no BAFFLES needed). At the same time this type of mixing is GENTLER on cells and produces less foam.

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