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Disease state of a patient can influence drug distribution across the body.(a) True(b) FalseI had been asked this question in exam.The above asked question is from Drug Distribution topic in chapter Distribution of Drugs of Drug Biotechnology

Answer»

Right answer is (a) True

Best explanation: Yes the statement is true since disease states can alter drug-protein binding, alter perfusion of the drug into any organ, and alter the pH of some TISSUE. In MENINGITIS and ENCEPHALITIS polar antibiotics gain ACCESS to BBB which don’t happen to a HEALTHY person.



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