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Why dopamine cannot be administered for the disease Parkinsonism?(a) Don’t have a medicine(b) It is not the medicine(c) Cannot cross the blood-brain barrier(d) Forms aggregate and thus cannot cross the BBBThe question was posed to me at a job interview.My question comes from Drug Distribution topic in portion Distribution of Drugs of Drug Biotechnology

Answer»

Right choice is (c) Cannot CROSS the blood-brain barrier

For explanation: The SELECTIVE PERMEABILITY of the lipid soluble moieties through the BBB does not allow several drugs to just pass the barrier. Parkinsonism cannot be treated by the administration of dopamine SINCE dopamine cannot cross the BBB.



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