Due to the translocation process, the XIC from one X chromosome in a woman passed to chromosome 3. The individual died. What were the probable reasons of death?(a) The X chromosome was unable to show its effect(b) Both X chromosome being active too much gene product was produced(c) Inactivation of chromosome 3(d) Hyper activation of autosomesThe question was posed to me in my homework.This is a very interesting question from Dosage Compensation Mechanism for X linked Genes in chapter Chromosomes and Sex Determination of Cytogenetics

Due to the translocation process, the XIC from one X chromosome in a w

1.	Due to the translocation process, the XIC from one X chromosome in a woman passed to chromosome 3. The individual died. What were the probable reasons of death?(a) The X chromosome was unable to show its effect(b) Both X chromosome being active too much gene product was produced(c) Inactivation of chromosome 3(d) Hyper activation of autosomesThe question was posed to me in my homework.This is a very interesting question from Dosage Compensation Mechanism for X linked Genes in chapter Chromosomes and Sex Determination of Cytogenetics
Answer» Correct ANSWER is (c) INACTIVATION of chromosome 3 The explanation: As XIC translocated to chromosome 3 now it can be counted as an X chromosome. In some cells randomly this chromosome 3 is condensed and inactivated which prevents the important AUTOSOMAL gene product from being formed. THUS the INDIVIDUAL dies.

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