Eukaryotic RNA polymerase II does not directly bind to the promoter, but relies on a dozen or more transcription factors to recognize and bind to the promoter in a specific order before its own binding around the promoter.(a) True(b) FalseThis question was addressed to me in examination.My enquiry is from Promoter and Regulatory Elements in Prokaryotes & Eukaryotes topic in section Promoter and Regulatory Element Prediction of Bioinformatics

Eukaryotic RNA polymerase II does not directly bind to the promoter, b

1.	Eukaryotic RNA polymerase II does not directly bind to the promoter, but relies on a dozen or more transcription factors to recognize and bind to the promoter in a specific order before its own binding around the promoter.(a) True(b) FalseThis question was addressed to me in examination.My enquiry is from Promoter and Regulatory Elements in Prokaryotes & Eukaryotes topic in section Promoter and Regulatory Element Prediction of Bioinformatics
Answer» The correct answer is (a) True Best explanation: The core of many eukaryotic PROMOTERS is a so-called TATA box, LOCATED 30 bps upstream from the transcription start site, having a consensus motif TATA (A/T) A (A/T). HOWEVER, not all eukaryotic promoters contain the TATA box. Many GENES such as housekeeping genes do not have the TATA box in their promoters.

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