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Which of the following is incorrect regarding Eponine?(a) It is a web-based program that predicts transcription start sites(b) It is a web-based program that particularly predicts tranpososons and retropososons(c) The regulatory sites include the TATA box, the CCAAT box, and CpG islands(d) It is based on a series of pre-constructed PSSMs of several regulatory sitesThis question was addressed to me in a job interview.This intriguing question originated from Prediction Algorithms topic in section Promoter and Regulatory Element Prediction of Bioinformatics

Answer»

The CORRECT option is (b) It is a web-based program that particularly predicts tranpososons and retropososons

The explanation is: The query sequence from a mammalian source is scanned through the PSSMs. The sequence stretches with high-score matching to all the PSSMs, as WELL as matching of the spacing between the ELEMENTS, are declared transcription start SITES. A Bayesian method is also used in DECISION making.



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