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How can you determine the extracellular fluid volume?(a) Evans blue(b) Na+(c) D20(d) Tritiated waterThis question was addressed to me during an online interview.This intriguing question comes from Drugs Distribution in chapter Distribution of Drugs of Drug Biotechnology

Answer» CORRECT option is (B) Na+

Easy explanation: ECF volume can be determined by substances which can easily penetrate the CAPILLARY membrane and distribute to the whole ECF but will not cross the membrane for e.g. Na+, Cl^–, Br^–, SCN^–, SO4^2-.


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