How pH alteration of the drug microenvironment is done?(a) Altering the pH while the administration(b) In situ salt formation(c) Altering the pH of the tissue(d) Formulating the drug in such a way that it gets activated only when it reaches the tissue pHI got this question in final exam.I want to ask this question from Bioavailability in section Compartment Modelling, Non Linear Pharmacokinetics, Bioavailability and Bioequivalence of Drug Biotechnology

How pH alteration of the drug microenvironment is done?(a) Altering th

1.	How pH alteration of the drug microenvironment is done?(a) Altering the pH while the administration(b) In situ salt formation(c) Altering the pH of the tissue(d) Formulating the drug in such a way that it gets activated only when it reaches the tissue pHI got this question in final exam.I want to ask this question from Bioavailability in section Compartment Modelling, Non Linear Pharmacokinetics, Bioavailability and Bioequivalence of Drug Biotechnology
Answer» Correct option is (b) In SITU salt formation Explanation: Alteration of pH of the drug microenvironment is done in two ways. One of that is in-situ salt formation, and other is the addition of BUFFERS to the formulation e.g. buffered aspirin tablets. We cannot DEPEND on tissue pH since it changes PERSON to person.

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