If the nick is at 5’ end of the mismatch which of the following will be recruited?(a) Rec J(b) Ruv D(c) Exonuclease I(d) Exonuclease XThis question was posed to me in unit test.The question is from Repair of DNA Damage: MMR, BER in portion DNA Mutation, DNA Repair, Transposable Elements of Cytogenetics

If the nick is at 5’ end of the mismatch which of the following will

1.	If the nick is at 5’ end of the mismatch which of the following will be recruited?(a) Rec J(b) Ruv D(c) Exonuclease I(d) Exonuclease XThis question was posed to me in unit test.The question is from Repair of DNA Damage: MMR, BER in portion DNA Mutation, DNA Repair, Transposable Elements of Cytogenetics
Answer» Correct ANSWER is (d) EXONUCLEASE X To explain: Rec J is an exonuclease which is also known as exonuclease VII. It is responsible for CHEWING the DNA from 5’ to 3’ direction. While exonuclease I and X chew from 3’ to 5’ direction which will not be of much use in this case.

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