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If there is an improper attachment of spindle fiber, which protein sends the negative signal?(a) Mcm(b) Mdm2(c) Mad2(d) MekThe question was posed to me in an interview for job.My enquiry is from Meiosis Prophase 1 : Zygotene topic in chapter Chromosomal Changes During Meiosis of Cytogenetics

Answer»

Right OPTION is (c) Mad2

The best explanation: Mad2 is responsible for signalling improper binding of the SPINDLE FIBER to the centromere. This negative signal PREVENTS apoptosis. Mdm2 is linked to p53 while Mcm activates ORC. Mek is a part of monomeric G protein signaling.



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