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In Jukes–Cantor Model to correct evolutionary distances, A formula for deriving evolutionary distances that include hidden changes is introduced by using a logarithmic function. It is ____(a) dAB = −(3/4) log[1 − (4/7)pAB](b) dAB = −(3/4) ln[1 − (5/3)pAB](c) dAB = −(3/4) log[1 − (4/3)pAB](d) dAB = −(3/4) ln[1 − (4/3)pAB]The question was posed to me in final exam.The doubt is from Forms of Tree Representation in section Molecular Phylogenetics of Bioinformatics

Answer»

Right option is (d) dAB = −(3/4) ln[1 − (4/3)pAB]

Best explanation: The simplest nucleotide substitution model is the Jukes–Cantor model, which ASSUMES that all NUCLEOTIDES are SUBSTITUTED with equal probability. dAB is the EVOLUTIONARY distance between sequences A and B and p AB is the observed sequence distance measured by the proportion of substitutions over the entire LENGTH of the alignment.



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