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In the given picture, the marking “a” represents the drug concentration of which compartment?(a) The central compartment in a two compartment model(b) A peripheral compartment in a two compartment model(c) The central compartment in a one compartment model(d) Drug concentration of the plasmaThe question was asked during an interview.My query is from One & Two Compartment Open Model topic in division Compartment Modelling, Non Linear Pharmacokinetics, Bioavailability and Bioequivalence of Drug Biotechnology

Answer»

The correct answer is (a) The central compartment in a TWO compartment MODEL

To EXPLAIN: In the graph, the MARKED curve is showing the drug concentration of the central compartment. Initially, the drug concentration of the central compartment in a two compartment model declines rapidly because of the rapid distribution of the drug from the central compartment to the peripheral compartment. This phase is known as the DISTRIBUTIVE phase.



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