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In the given picture, which kinetic order the graph is following at the marked place?(a) 1st order kinetics(b) 2nd order kinetics(c) Mixed order kinetics(d) Zero-order rateI got this question in unit test.The above asked question is from Non Linearity of Drugs topic in portion Compartment Modelling, Non Linear Pharmacokinetics, Bioavailability and Bioequivalence of Drug Biotechnology

Answer»

Right choice is (d) Zero-order RATE

Explanation: The plot is of Michaelis-Menten EQUATION –dC/dt = Vmax C/Km+C, Initially the rate INCREASES linearly with CONCENTRATION thus showing first order kinetics. At lower doses, it follows 1st order kinetics. It becomes mixed order at intermediate doses and then reaches maximum Vmax. Beyond this, it proceeds at a constant rate thus following zero order kinetics.



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