In vitro determination of bioavailability by dissolution rate is not the best way to determine therapeutic efficacy.(a) True(b) FalseI have been asked this question during an interview for a job.The question is from Bioavailability in portion Compartment Modelling, Non Linear Pharmacokinetics, Bioavailability and Bioequivalence of Drug Biotechnology

In vitro determination of bioavailability by dissolution rate is not t

1.	In vitro determination of bioavailability by dissolution rate is not the best way to determine therapeutic efficacy.(a) True(b) FalseI have been asked this question during an interview for a job.The question is from Bioavailability in portion Compartment Modelling, Non Linear Pharmacokinetics, Bioavailability and Bioequivalence of Drug Biotechnology
Answer» Correct option is (b) False For explanation I would say: Physicochemical property of most of the drugs that have the greatest influence on their ABSORPTION characteristics from the gastrointestinal tract is dissolution rate. To assess the therapeutic efficacy of slow dissolving drugs is in VIVO determination of bioavailability. It is DONE WHENEVER a new formulation is to be INTRODUCED in the market.

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