Multiple dose study is better since we can understand the peak, valley, drug blood levels, etc.(a) True(b) FalseI had been asked this question in a national level competition.My doubt is from Bioavailability in portion Compartment Modelling, Non Linear Pharmacokinetics, Bioavailability and Bioequivalence of Drug Biotechnology

Multiple dose study is better since we can understand the peak, valley

1.	Multiple dose study is better since we can understand the peak, valley, drug blood levels, etc.(a) True(b) FalseI had been asked this question in a national level competition.My doubt is from Bioavailability in portion Compartment Modelling, Non Linear Pharmacokinetics, Bioavailability and Bioequivalence of Drug Biotechnology
Answer» The correct ANSWER is (a) True For explanation: MULTIPLE dose study is difficult to control since it exposes the SUBJECT to a higher level of drug which is dangerous sometimes. This method is very tedious and time-consuming. The advantages of such method are ACCURATELY reflected how the drug should be used, easy to predict peak and valley of a drug, can be ethically performed on the PATIENT, better evaluation of the performance of controlled release formulation is possible.

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