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Mut H acts as ______________(a) Adaptor(b) Exonuclease(c) Endonuclease(d) HelicaseThis question was addressed to me at a job interview.My enquiry is from Repair of DNA Damage: MMR, BER topic in chapter DNA Mutation, DNA Repair, Transposable Elements of Cytogenetics

Answer»

The correct option is (c) Endonuclease

To EXPLAIN: Mut H can bind to hemi-methylated DNA and make a NICK in the strand with unmethylated GATC sequence. As it MAKES a nick within the DNA it is an endonuclease.



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