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P53 requires ________________for its activity.(a) Mdm(b) MCM(c) Securin(d) CdtThis question was addressed to me during an interview.I would like to ask this question from Overview of Cell Reproduction in section Chromosomal Changes During Meiosis of Cytogenetics

Answer»

Right choice is (a) MDM

The best explanation: P53 prevents cell cycle progression during DNA damage. This is mediated with the help of Mdm which helps it to INDUCE transcription of P21 that helps prevent a CONTINUATION of cell cycle.



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