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Poor bioavailability means poor aqueous solubility.(a) True(b) FalseI have been asked this question in an interview for job.This question is from Bioavailability topic in portion Compartment Modelling, Non Linear Pharmacokinetics, Bioavailability and Bioequivalence of Drug Biotechnology

Answer»

The correct choice is (a) True

For explanation: A drug with poor bioavailability means the drug can also have poor aqueous solubility, slow dissolution rate in plasma or other BIOLOGICAL fluids. The drug can also have poor stability of the dissolved drug at the patient’s body pH, inadequate PARTITION coefficient, and EXTENSIVE presystemic METABOLISM.



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