Sickle cell anemia is a result of _______________(a) Non sense mutation(b) Mis-sense mutation(c) Sense mutation(d) Frame shift mutationI had been asked this question in an online quiz.My doubt stems from DNA Mutation topic in portion DNA Mutation, DNA Repair, Transposable Elements of Cytogenetics

Sickle cell anemia is a result of _______________(a) Non sense mutatio

1.	Sickle cell anemia is a result of _______________(a) Non sense mutation(b) Mis-sense mutation(c) Sense mutation(d) Frame shift mutationI had been asked this question in an online quiz.My doubt stems from DNA Mutation topic in portion DNA Mutation, DNA Repair, Transposable Elements of Cytogenetics
Answer» Correct option is (b) Mis-sense mutation Best explanation: In this disease, a GAG is CONVERTED to a GUG, i.e a glutamic ACID is converted to a valine. This is example of a mis-sense mutation where a CHANGE of base codes for a different amino acid from the ORIGINAL.

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