I've Installed Age Of Mythology the day before yesterday.
It worked well that day now today I want to play it and after the 2 movies I get the error message: "Initializing failed!"
If I remove the program and run Ccleaner at the ISSUE part afterwards.
The reinstall it than I can play it but if I reboot my PC then I get the error message again.
How is this POSSIBLE?
What can I do about it?
I would give you more info if I had it.

Jonas I know this can be much but I'll everything you suggest and I'll keep you up-to-date.

Jonas were there any corrupted files before you reinstalled it?No I THINK that they are removed by Ccleaner and CHKDSK.

Jonas I've found a breakthrough.
AOM has a a mode where you can play Without the sound.
That Works fine.
Sow I think that it is my sound program that CREATES the error.
I use SOUNDMAX Digital Audio.
I don't know how I can give you more info about that but if you need more info just tell me how I get to that info and I'll give it to you.
I Also suggest a mod move this to software because now it isn't any more about the game but about my sound program.

Jonas