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The XXY klinefelter survive but trisomy in most autosome is lethal. Why?(a) Autosome carries more genes(b) Autosomes have better dominant recessive relations(c) X chromosomes are inactivated(d) Autosomes are more in numberThe question was posed to me in an online interview.This interesting question is from Dosage Compensation Mechanism for X linked Genes in division Chromosomes and Sex Determination of Cytogenetics

Answer»

Right choice is (c) X chromosomes are inactivated

To explain: Due to dosage COMPENSATION only ONE X CHROMOSOME in XXY says active. So the EFFECT of excess X chromosome is somewhat mitigated. In autosome there is no such inactivation and excess of GENE products leads to lethality.



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