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What is a negative regulator of Cdc-20?(a) M-Cdk(b) Mad-2(c) Mdm(d) Hct1This question was posed to me during a job interview.My doubt stems from Overview of Cell Reproduction in chapter Chromosomal Changes During Meiosis of Cytogenetics

Answer»

Correct ANSWER is (b) Mad-2

The BEST explanation: Mad 2 bind to unbound KINETOCHORES, which leads to inactivation of Cdc-20. This is a checkpoint that makes sure anaphase only occurs when all the centromeres are bound to spindle. M-Cdk and HCT1 promote activity, while Mdm is not directly LINKED to its activity.



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