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What is the equation to find out hepatic clearance?(a) Plasma drug concentration/rate of elimination by the kidney(b) Rate of elimination by kidney/plasma drug concentration(c) 1 / rate of elimination by the kidney(d) 1 / plasma drug concentrationI had been asked this question by my school principal while I was bunking the class.Enquiry is from One & Two Compartment Open Model in section Compartment Modelling, Non Linear Pharmacokinetics, Bioavailability and Bioequivalence of Drug Biotechnology

Answer»

Correct OPTION is (b) Rate of elimination by kidney/PLASMA drug concentration

The EXPLANATION: The HEPATIC clearance is given by the equation Rate of elimination by kidney/plasma drug concentration. The RENAL clearance is given by the equation Rate of elimination by liver/ plasma drug concentration.



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