What is the principle behind the use of surfactants?(a) Reducing the size of solid drug particles(b) Enhancing the dissolution rate by promoting wetting(c) Improving solubility(d) Alter the pH of the microenvironmentThis question was posed to me in an interview.My question comes from Bioavailability in portion Compartment Modelling, Non Linear Pharmacokinetics, Bioavailability and Bioequivalence of Drug Biotechnology

What is the principle behind the use of surfactants?(a) Reducing the s

1.	What is the principle behind the use of surfactants?(a) Reducing the size of solid drug particles(b) Enhancing the dissolution rate by promoting wetting(c) Improving solubility(d) Alter the pH of the microenvironmentThis question was posed to me in an interview.My question comes from Bioavailability in portion Compartment Modelling, Non Linear Pharmacokinetics, Bioavailability and Bioequivalence of Drug Biotechnology
Answer» Correct CHOICE is (b) Enhancing the dissolution rate by PROMOTING wetting To explain I would say: Surfactants enhance the dissolution rate by promoting wetting and penetration of dissolution fluid into the solid DRUG particles. These surfactants are used in a CONCENTRATION below the critical micellar concentration since above CMC the trapped drug in the micelle structure fails to partition in the dissolution fluid.

Discussion

No Comment Found

Related InterviewSolutions

In the below picture which form of solid solution of griseofulvin with succinic acid is shown?(a) Solid solution(b) Eutectic mixture(c) Micronized drug(d) Coarse drugThe question was asked in class test.My doubt is from Bioavailability in portion Compartment Modelling, Non Linear Pharmacokinetics, Bioavailability and Bioequivalence of Drug Biotechnology
Which one of the following is used for selective adsorption on insoluble carriers of the drugs?(a) Freeze drying(b) Organic solvent(c) Inorganic clays like bentonite(d) Creating metastable polymorphsThis question was posed to me in quiz.I'm obligated to ask this question of Bioavailability in chapter Compartment Modelling, Non Linear Pharmacokinetics, Bioavailability and Bioequivalence of Drug Biotechnology
Two or more drugs contain the same therapeutically active ingredient which elicits same pharmacological effects and can control the disease to the same extent are known to be pharmaceutic equivalent.(a) True(b) FalseI had been asked this question in an online quiz.The doubt is from Bioequivalence Studies in section Compartment Modelling, Non Linear Pharmacokinetics, Bioavailability and Bioequivalence of Drug Biotechnology
Find out the correct option for the marked place in the given picture of the rate of excretion versus midpoint time of urine collection period curve.(a) (dXu/dt)max(b) (tu)max(c) Xu(d) CmaxI had been asked this question in class test.The question is from Bioavailability in section Compartment Modelling, Non Linear Pharmacokinetics, Bioavailability and Bioequivalence of Drug Biotechnology
Which of the following is not a category of 2 compartment model?(a) Two compartment model with elimination from the central compartment(b) Two compartment model with elimination from the peripheral compartment(c) Two compartment model with elimination from only plasma and blood(d) Two compartment model with elimination from both the compartmentsI have been asked this question at a job interview.This key question is from One & Two Compartment Open Model topic in division Compartment Modelling, Non Linear Pharmacokinetics, Bioavailability and Bioequivalence of Drug Biotechnology
What will be the particle size after micronization of drugs?(a) 1-10 micron(b) 10-20 micron(c) 20-30 micron(d) 1-5 micronI had been asked this question in an online interview.My doubt stems from Bioavailability topic in section Compartment Modelling, Non Linear Pharmacokinetics, Bioavailability and Bioequivalence of Drug Biotechnology
What is therapeutic equivalence?(a) Two or more drug products contain the same labeled chemical substance in the same amount(b) Two or more drug products contain the same labeled chemical substance in different quantity(c) Two or more drug products contain the same labeled chemical substance giving the same therapeutic effect(d) Two or more drug products contain the same labeled chemical substance giving a different therapeutic effectThe question was posed to me during an internship interview.My doubt is from Bioequivalence Studies topic in section Compartment Modelling, Non Linear Pharmacokinetics, Bioavailability and Bioequivalence of Drug Biotechnology
Which of the following will not be a parameter that should be examined for urinary excretion data?(a) (dXu/dt)max(b) (tu)max(c) Xu(d) CmaxI got this question during an online exam.My question is taken from Bioavailability in chapter Compartment Modelling, Non Linear Pharmacokinetics, Bioavailability and Bioequivalence of Drug Biotechnology
In the given picture, which kinetic order the graph is following at the marked place?(a) 1st order kinetics(b) 2nd order kinetics(c) Mixed order kinetics(d) 1st order at higher dosesThis question was posed to me at a job interview.I want to ask this question from Non Linearity of Drugs topic in section Compartment Modelling, Non Linear Pharmacokinetics, Bioavailability and Bioequivalence of Drug Biotechnology
Which of the following is used in molecular encapsulation of drugs for enhancing bioavailability?(a) Highly water-soluble compound(b) Cyclodextrin(c) Inorganic clays like bentonite(d) Creating metastable polymorphsThis question was addressed to me during an interview.My doubt stems from Bioavailability topic in chapter Compartment Modelling, Non Linear Pharmacokinetics, Bioavailability and Bioequivalence of Drug Biotechnology

Discussion

No Comment Found

Related InterviewSolutions

Reply to Comment