What should be the disadvantage of cross over study on volunteers?(a) Minimize the intersubject variability in plasma drug levels(b) Minimize the carry-over effect(c) Minimizes variations due to time effect(d) Takes a lot of time to get the result of the studyI had been asked this question during a job interview.This question is from Bioequivalence Studies topic in division Compartment Modelling, Non Linear Pharmacokinetics, Bioavailability and Bioequivalence of Drug Biotechnology

What should be the disadvantage of cross over study on volunteers?(a)

1.	What should be the disadvantage of cross over study on volunteers?(a) Minimize the intersubject variability in plasma drug levels(b) Minimize the carry-over effect(c) Minimizes variations due to time effect(d) Takes a lot of time to get the result of the studyI had been asked this question during a job interview.This question is from Bioequivalence Studies topic in division Compartment Modelling, Non Linear Pharmacokinetics, Bioavailability and Bioequivalence of Drug Biotechnology
Answer» Right answer is (d) Takes a lot of time to get the result of the study Best explanation: The ADVANTAGES of randomized, balanced, cross-over study is it minimizes the intersubject VARIABILITY in plasma drug LEVELS, minimize the carry-over EFFECT, minimizes variations due to time effect, makes it possible to focus on formulation variables. But this METHOD takes a long time because a specific time has to be given for the washout of the previous administration.

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