Which of the bond in the nucleotide is broken 1st in BER?(a) Bond between two consequent bases(b) Bond between base and sugar(c) Bond between base and phosphate(d) Bond between two complementary basesThe question was posed to me in a job interview.This is a very interesting question from Repair of DNA Damage: MMR, BER topic in portion DNA Mutation, DNA Repair, Transposable Elements of Cytogenetics

Which of the bond in the nucleotide is broken 1st in BER?(a) Bond betw

1.	Which of the bond in the nucleotide is broken 1st in BER?(a) Bond between two consequent bases(b) Bond between base and sugar(c) Bond between base and phosphate(d) Bond between two complementary basesThe question was posed to me in a job interview.This is a very interesting question from Repair of DNA Damage: MMR, BER topic in portion DNA Mutation, DNA Repair, Transposable Elements of Cytogenetics
Answer» Correct choice is (B) Bond between base and sugar To elaborate: The glycosidic bond between the sugar residue and the nitrogenous base is the 1st to be BROKEN by BER glycosylases GENERATING an ABASIC SITE.

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