Which of the factors are necessary in TC NER but not in GG NER?(a) hHR23B(b) ERCCI- XPF(c) CSA(d) RAD23This question was posed to me during an interview.My question is based upon Repair of DNA Damage: NER, Direct Reversal in portion DNA Mutation, DNA Repair, Transposable Elements of Cytogenetics

Which of the factors are necessary in TC NER but not in GG NER?(a) hHR

1.	Which of the factors are necessary in TC NER but not in GG NER?(a) hHR23B(b) ERCCI- XPF(c) CSA(d) RAD23This question was posed to me during an interview.My question is based upon Repair of DNA Damage: NER, Direct Reversal in portion DNA Mutation, DNA Repair, Transposable Elements of Cytogenetics
Answer» CORRECT answer is (C) CSA Easy explanation: The factors CSA and CSB help the RNA POLYMERASE to backtrack when it ENCOUNTERS a lesion. However, hHR23B in association with XPC is more necessary in GG NER to detect the lesion.

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