Which of the following can act as an intragenic suppressor mutation to a Frame shift mutation?(a) Transition(b) Missense mutation(c) Another frame shift mutation(d) Non sense mutationThe question was asked in quiz.My enquiry is from DNA Mutation topic in chapter DNA Mutation, DNA Repair, Transposable Elements of Cytogenetics

Which of the following can act as an intragenic suppressor mutation to

1.	Which of the following can act as an intragenic suppressor mutation to a Frame shift mutation?(a) Transition(b) Missense mutation(c) Another frame shift mutation(d) Non sense mutationThe question was asked in quiz.My enquiry is from DNA Mutation topic in chapter DNA Mutation, DNA Repair, Transposable Elements of Cytogenetics
Answer» Correct answer is (c) Another FRAME shift mutation To explain: If OVERALL the two frame shift MUTATIONS LEAD to a change of 3 or its multiple in the genetic code, the codons will again be in the same frame. This is an internal compensation, so intragenic SUPPRESSION.

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