Which of the following displaces Importin-alpha from the cargo transported inside the nucleus?(a) Impotin-beta(b) RanGTP(c) CAS(d) RanGTPaseThis question was addressed to me by my school teacher while I was bunking the class.The question is from Nucleus topic in portion Nucleus & Aerobic Respiration of Cell Biology

Which of the following displaces Importin-alpha from the cargo transpo

1.	Which of the following displaces Importin-alpha from the cargo transported inside the nucleus?(a) Impotin-beta(b) RanGTP(c) CAS(d) RanGTPaseThis question was addressed to me by my school teacher while I was bunking the class.The question is from Nucleus topic in portion Nucleus & Aerobic Respiration of Cell Biology
Answer» The correct option is (c) CAS Best explanation: Once the complex composed of importin-alpha—importin-beta—molecule enters the NUCLEUS, the importin-alpha and importin-beta has to be removed. RANGTP BINDS to Importin-beta and displaces it from the complex. Then the Cellular Apoptosis Susceptibility (CAS) protein which is an exportin and is bound to RanGTP, displaces Importin-alpha from the molecule with NLS sequence.

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