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Which of the following first binds to the NLS protein sequence?(a) Importin-alpha(b) Importin-beta(c) CAS protein(d) NLS detecting proteinThis question was addressed to me in class test.The doubt is from Nucleus topic in chapter Nucleus & Aerobic Respiration of Cell Biology

Answer»

Correct option is (a) Importin-alpha

Easiest explanation: The molecules that contain NUCLEUS LOCALIZATION Signal (NLS) sequence, are immediately ushered into the nucleus through nucleopore. The first step of this transport involves binding of importin-alpha to the NLS sequence, which then acts as a BRIDGE for the ATTACHMENT of importin-beta.



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