Which of the following is a neutral mutation?(a) Replacement of a Glu by Val(b) Replacement of AAA by UAA(c) Replacement of Lys by Arg(d) Replacement of Thr by TyrI had been asked this question during a job interview.This intriguing question originated from DNA Mutation in division DNA Mutation, DNA Repair, Transposable Elements of Cytogenetics

Which of the following is a neutral mutation?(a) Replacement of a Glu

1.	Which of the following is a neutral mutation?(a) Replacement of a Glu by Val(b) Replacement of AAA by UAA(c) Replacement of Lys by Arg(d) Replacement of Thr by TyrI had been asked this question during a job interview.This intriguing question originated from DNA Mutation in division DNA Mutation, DNA Repair, Transposable Elements of Cytogenetics
Answer» Right choice is (c) Replacement of LYS by Arg For EXPLANATION I would say: Lys and Arg are both basic amino acid of similar SIZE, thus the mutation of one with another doesn’t have much effect on the final protein structure or function. On the other hand, option b is a nonsense mutation, and a and d are missense mutation.

Discussion

No Comment Found

Related InterviewSolutions

Which of the following will be seen to resolve the flap in eukaryotic short patch BER?(a) dRPases(b) FEN1(c) Pol Beta(d) APE1This question was addressed to me in homework.My doubt is from Repair of DNA Damage: MMR, BER in section DNA Mutation, DNA Repair, Transposable Elements of Cytogenetics
Which of the following modes of repair is restricted to S phase of the cell cycle?(a) BER(b) MMR(c) NER(d) DSBI had been asked this question in exam.My query is from Repair of DNA Damage: MMR, BER topic in portion DNA Mutation, DNA Repair, Transposable Elements of Cytogenetics
Which sequences among these will have a preference for frame shift?(a) TTTTTTTTTTTTTTT(b) AUGATTCT(c) CATGCATGCATG(d) AUGCTGTCGUAThe question was posed to me in final exam.Question is taken from DNA Mutation in section DNA Mutation, DNA Repair, Transposable Elements of Cytogenetics
Which of the following is most flexible ligase?(a) Ligase I(b) ERCCI(c) Ligase IV(d) Ligase XThe question was posed to me in unit test.This is a very interesting question from Repair of DNA Damage: Recombinational and Bypass topic in division DNA Mutation, DNA Repair, Transposable Elements of Cytogenetics
What is the structure of Rec A filament?(a) Cylindrical(b) Straight(c) Like rolled beta sheet(d) Alpha helicalI have been asked this question in quiz.My doubt is from Repair of DNA Damage: Recombinational and Bypass topic in division DNA Mutation, DNA Repair, Transposable Elements of Cytogenetics
It is good that Guanine methyl transferase is absent in human beings.(a) True(b) FalseI had been asked this question in a national level competition.This interesting question is from Repair of DNA Damage: NER, Direct Reversal topic in section DNA Mutation, DNA Repair, Transposable Elements of Cytogenetics
You are studying a mutational hot spot in the promoter region of a gene. Which type of mutation will you expect the most in this case?(a) Deamination(b) Depurination(c) Methylation(d) Frame shiftI had been asked this question in an online interview.The origin of the question is DNA Mutation topic in portion DNA Mutation, DNA Repair, Transposable Elements of Cytogenetics
Defect in which of these genes produce an increased propensity to breast cancer?(a) MTHF poly glu(b) PKC(c) BRCA 1(d) XPBI had been asked this question in an interview for job.I'd like to ask this question from Repair of DNA Damage: Recombinational and Bypass topic in division DNA Mutation, DNA Repair, Transposable Elements of Cytogenetics
Which of the following is not a function of APE1?(a) 5’->3’ exonuclease(b) Generating nick at 5’ end(c) Generating abasic site(d) Improving fidelity of pol betaThis question was addressed to me in an international level competition.My enquiry is from Repair of DNA Damage: MMR, BER in division DNA Mutation, DNA Repair, Transposable Elements of Cytogenetics
Which of the DNA polymerase in eukaryotes is responsible for repair synthesis of the excised strand in NER?(a) Pol epsilon(b) Pol III(c) Pol beta(d) Pol IThis question was posed to me in an online interview.My doubt stems from Repair of DNA Damage: NER, Direct Reversal in portion DNA Mutation, DNA Repair, Transposable Elements of Cytogenetics

Discussion

No Comment Found

Related InterviewSolutions

Reply to Comment