Which of the following is not true about NHEJ?(a) In most of the cases, it is associated with loss of genetic material(b) Ku is present at a concentration as high as 400000 per cell(c) It strand invasion looks for micro-homology regions(d) The 3’overhang chewed up to chi sequence invades to search for homologyThis question was addressed to me during an internship interview.I would like to ask this question from Repair of DNA Damage: Recombinational and Bypass in chapter DNA Mutation, DNA Repair, Transposable Elements of Cytogenetics

Which of the following is not true about NHEJ?(a) In most of the cases

1.	Which of the following is not true about NHEJ?(a) In most of the cases, it is associated with loss of genetic material(b) Ku is present at a concentration as high as 400000 per cell(c) It strand invasion looks for micro-homology regions(d) The 3’overhang chewed up to chi sequence invades to search for homologyThis question was addressed to me during an internship interview.I would like to ask this question from Repair of DNA Damage: Recombinational and Bypass in chapter DNA Mutation, DNA Repair, Transposable Elements of Cytogenetics
Answer» Right ANSWER is (d) The 3’overhang CHEWED up to chi sequence invades to search for homology The BEST I can explain: In NHEJ to REDUCE the LOSS of genetic information and for a quicker search of homology domains the 3’ over hand is only 4 nt long. This increases the probability of fining micro homology region as well as prevents loss.

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