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Which of the following is used in the solvent deposition method of enhancing bioavailability?(a) Freeze drying(b) Organic solvent(c) Inorganic clays like bentonite(d) Creating metastable polymorphsI got this question during an interview.The above asked question is from Bioavailability in division Compartment Modelling, Non Linear Pharmacokinetics, Bioavailability and Bioequivalence of Drug Biotechnology

Answer»

The correct answer is (b) Organic solvent

For explanation: INSOLVENT deposition method, poorly aqueous SOLUBLE DRUGS are dissolved in an organic solvent such as alcohol and deposited on an inert, HYDROPHILIC, solid matrix such as that of STARCH or microcrystalline cellulose by evaporation of the solvent.



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