Which of the following mutation will lead to AT->GC transition?(a) Nitrous acid acting on A(b) Nitrous acid on C(c) Hydroxylation of C(d) Methylation of GI got this question in an interview.The origin of the question is DNA Mutation topic in division DNA Mutation, DNA Repair, Transposable Elements of Cytogenetics

Which of the following mutation will lead to AT->GC transition?(a) Nit

1.	Which of the following mutation will lead to AT->GC transition?(a) Nitrous acid acting on A(b) Nitrous acid on C(c) Hydroxylation of C(d) Methylation of GI got this question in an interview.The origin of the question is DNA Mutation topic in division DNA Mutation, DNA Repair, Transposable Elements of Cytogenetics
Answer» The correct option is (a) Nitrous acid acting on A Explanation: All options other than OXIDATION of A by nitrous acid LEAD to GC->AT transition. Nitrous acid converts A to Hypoxanthine that in place of pairing with T pairs with C. THUS, it LEADS to AT->GC transition.

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