Which of the following will be a marker of DSB?(a) H2A(b) Gamma-P H2AX(c) H5G(d) Alpha-P H3BXThe question was posed to me in a job interview.This intriguing question comes from Repair of DNA Damage: Recombinational and Bypass in section DNA Mutation, DNA Repair, Transposable Elements of Cytogenetics

Which of the following will be a marker of DSB?(a) H2A(b) Gamma-P H2AX

1.	Which of the following will be a marker of DSB?(a) H2A(b) Gamma-P H2AX(c) H5G(d) Alpha-P H3BXThe question was posed to me in a job interview.This intriguing question comes from Repair of DNA Damage: Recombinational and Bypass in section DNA Mutation, DNA Repair, Transposable Elements of Cytogenetics
Answer» The correct OPTION is (B) Gamma-P H2AX For explanation: In DSB the canonical bases are replaced by the non-canonical bases, which it also phosphorylated by ATM kinase.H2AX is one such non-cannonical base, while there is no H3BX or H5G. H2AX is phosphorylated at gamma not alpha.

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