Which of the following will prevent cell cycle from progressing in case of DNA damage?(a) P53(b) G1 cyclin(c) P10(d) Bcl-2I have been asked this question during a job interview.I'd like to ask this question from Overview of Cell Reproduction topic in portion Chromosomal Changes During Meiosis of Cytogenetics

Which of the following will prevent cell cycle from progressing in cas

1.	Which of the following will prevent cell cycle from progressing in case of DNA damage?(a) P53(b) G1 cyclin(c) P10(d) Bcl-2I have been asked this question during a job interview.I'd like to ask this question from Overview of Cell Reproduction topic in portion Chromosomal Changes During Meiosis of Cytogenetics
Answer» The correct option is (a) P53 To elaborate: In case of DNA DAMAGE P53 SENSES the damage in DNA and blocks the further progression of the cell cycle UNLESS the damage is repaired. This can EVEN lead to apoptosis if the damage stays as it is.

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